T3932

Tyrphostin AG 1295

≥98%

• Synonym(e): 6,7-Dimethyl-2-phenylquinoxaline
• Empirische Formel (Hill-System): C₁₆H₁₄N₂
• CAS-Nummer: 71897-07-9
• Molekulargewicht: 234.30
• UNSPSC Code: 12352200
• PubChem Substance ID: 24900180
• MDL number: MFCD00270912

Eigenschaften

• assay: ≥98%
• solubility: 0.1 M HCl: soluble <1 mg/mL, ethanol: soluble 10 mg/mL, methylene chloride: soluble 10 mg/mL, 0.1 M NaOH: insoluble, 2-hydroxypropyl-β-cyclodextrin: insoluble, H₂O: insoluble
• storage temp.: −20°C
• SMILES string: Cc1cc2ncc(nc2cc1C)-c3ccccc3
• Gene Information: human ... EGFR(1956), FLT3(2322), PDGFRB(5159), SRC(6714) ; mouse ... Pdgfrb(18596)

Beschreibung

Application

Tyrphostin AG 1295 has been used as an Flt3 inhibitor in NA10 and ND13 progenitor cell lines². Studies using AG 1295 have reported that it can reduce cell division and DNA synthesis induced by nicotine in human aortic vascular smooth muscle cells³.

Tyrphostin AG 1295 is soluble in methylene chloride at 10 mg/ml, in ethanol at 10 mg/ml and in 0.1 N HCl at less than 1 mg/ml. It is however, insoluble in water, 0.1 N sodium hydroxide, and 2-hydroxypropyl-β-cyclodextrin.

Biochem/physiol Actions

Selective inhibitor of tyrosine kinase in platelet-derived growth factor (PDGF) receptor.

Studies in mouse osteoblastic MC3T3-E1 cells have reported that AG 1295 can enhance matrix mineralization and osteoblast differentiation by inhibiting PDGFR-β signaling⁴.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)