T3932

Tyrphostin AG 1295

≥98%

• Synonym(e): 6,7-Dimethyl-2-phenylquinoxaline
• Empirische Formel (Hill-System): C₁₆H₁₄N₂
• CAS-Nummer: 71897-07-9
• Molekulargewicht: 234.30
• MDL-Nummer: MFCD00270912
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24900180

Eigenschaften

• Assay: ≥98%
• Löslichkeit: 0.1 M HCl: soluble <1 mg/mL; ethanol: soluble 10 mg/mL; methylene chloride: soluble 10 mg/mL; 0.1 M NaOH: insoluble; 2-hydroxypropyl-β-cyclodextrin: insoluble; H₂O: insoluble
• Lagertemp.: −20°C
• SMILES String: Cc1cc2ncc(nc2cc1C)-c3ccccc3
• Angaben zum Gen: human ... EGFR(1956) , FLT3(2322) , PDGFRB(5159) , SRC(6714) ; mouse ... Pdgfrb(18596)

Beschreibung

Anwendung

Tyrphostin AG 1295 has been used as an Flt3 inhibitor in NA10 and ND13 progenitor cell lines². Studies using AG 1295 have reported that it can reduce cell division and DNA synthesis induced by nicotine in human aortic vascular smooth muscle cells³.

Tyrphostin AG 1295 is soluble in methylene chloride at 10 mg/ml, in ethanol at 10 mg/ml and in 0.1 N HCl at less than 1 mg/ml. It is however, insoluble in water, 0.1 N sodium hydroxide, and 2-hydroxypropyl-β-cyclodextrin.

Biochem./physiol. Wirkung

Studies in mouse osteoblastic MC3T3-E1 cells have reported that AG 1295 can enhance matrix mineralization and osteoblast differentiation by inhibiting PDGFR-β signaling⁴.

Selective inhibitor of tyrosine kinase in platelet-derived growth factor (PDGF) receptor.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)