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T0410

Sigma-Aldrich

Tiapride hydrochloride

Synonym(e):

N-[2-(Diethylamino)ethyl]-5-(methylsulfonyl)-o-anisamide hydrochloride

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About This Item

Empirische Formel (Hill-System):
C15H24N2O4S · HCl
CAS-Nummer:
51012-32-9
Molekulargewicht:
364.89
EG-Nummer:
256-908-4
MDL-Nummer:
MFCD00133861
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278720

Lagertemp.

2-8°C

SMILES String

Cl.CCN(CC)CCNC(=O)c1cc(ccc1OC)S(C)(=O)=O

InChI

1S/C15H24N2O4S.ClH/c1-5-17(6-2)10-9-16-15(18)13-11-12(22(4,19)20)7-8-14(13)21-3;/h7-8,11H,5-6,9-10H2,1-4H3,(H,16,18);1H

InChIKey

OTFDPNXIVHBTKW-UHFFFAOYSA-N

Angaben zum Gen

human ... DRD2(1813) , DRD3(1814)

Anwendung

Tiapride and inhibitor of nitric oxide synthase were coadministered to mice to study the effect of dopamine D2 transmission in catalepsy.

Biochem./physiol. Wirkung

Tiapride, an atypical neuroleptic agent, antagonizes D2 and D3 dopamine receptors. It exhibits anti-dyskinetic and anxiolytic activities. It is effective in the management of alcohol withdrawal and treatment of tic disease in children.

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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M S Lidow et al.
The Journal of pharmacology and experimental therapeutics, 283(2), 939-946 (1997-11-14)
The RNase Protection Assay was used to examine the regulation of D2 and D4 dopamine receptor mRNAs in the cerebral cortex and neostriatum of nonhuman primates after chronic treatment with a wide spectrum of antipsychotic medications (chlorpromazine, clozapine, haloperidol, molindone
Maria Cavas et al.
Progress in neuro-psychopharmacology & biological psychiatry, 26(1), 69-73 (2002-02-21)
This study was designed to determine the possible potentiation of catalepsy behavior after coadministration of N(G)-nitro-L-arginine (L-NOARG), an inhibitor of nitric oxide synthase (NOS), and tiapride, a specific antagonist for D2 receptors, in male mice. Catalepsy was measured by the
C Eggers et al.
European archives of psychiatry and neurological sciences, 237(4), 223-229 (1988-01-01)
Tiapride, a substituted benzamide derivative, possesses good clinical antidyskinetic properties due to its DA2-blocking activities. It has been shown to be clinically effective in the treatment of tic disease in children. In order to study tiapride's antidyskinetic properties in the
C Cohen et al.
The Journal of pharmacology and experimental therapeutics, 283(2), 566-573 (1997-11-14)
The ability of tiapride, a selective D2/D3 dopamine receptor antagonist, to exert discriminative stimulus control of responding was investigated by training rats to discriminate this drug (30 mg/kg) from saline in a two-lever, food-reinforcement procedure. Acquisition of tiapride discrimination required
D H Peters et al.
Drugs, 47(6), 1010-1032 (1994-06-01)
Tiapride, an atypical neuroleptic agent, is a selective dopamine D2-receptor antagonist with little propensity for causing catalepsy and sedation. It shows preferential activity at receptors previously sensitised to dopamine and those located extrastriatally. Tiapride demonstrates antidyskinetic activity reflecting antidopaminergic actions
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