SRP8028

DR6 (human): FC (human)

recombinant, expressed in HEK 293 cells, >95% (SDS-PAGE)

• Synonym(e): CD358, TNFRSF21, Tumor necrosis factor receptor superfamily member 21
• UNSPSC-Code: 12352202
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human
• Rekombinant: expressed in HEK 293 cells
• Assay: >95% (SDS-PAGE)
• Form: lyophilized
• Mol-Gew.: ~80 kDa by SDS-PAGE
• Verpackung: pkg of 50 μg
• Lagerbedingungen: avoid repeated freeze/thaw cycles
• Verunreinigungen: <0.1 EU/μg endotoxin, tested
• Farbe: white
• UniProt-Hinterlegungsnummer: O75509
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... TNFRSF21(27242)

Beschreibung

Allgemeine Beschreibung

DR6 is an orphan TNF receptor superfamily member belonging to a subgroup of receptors called death receptors. Expressed ubiquitously with high expression in lymphoid organs, heart, brain, and pancreas. Broadly expressed by developing neurons where it functions as pro-apoptotic factor. Recently, it has been reported that interaction with the beta-amyloid precursor protein (APP) activates a widespread caspase-dependent self-destruction program dependent on caspase-6.

Physikalische Form

Lyophilized from PBS.

Rekonstituierung

Reconstitute with 50 μL deionized water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.

Sonstige Hinweise

The Fc portion of human IgG1 is fused to the C-terminus of human DR6 (aa 42-351).

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable