SML3872

AZ0108

≥98% (HPLC)

• Synonym(e): (S)-4-((3-(3-(1,1-difluoroethyl)-6-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)phenyl)difluoromethyl)phthalazin-1(2H)-one, 4-[[3-[[(6S)-3-(1,1-Difluoroethyl)-5,6-dihydro-6-methyl-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl]phenyl]difluoromethyl]-1(2H)-phthalazinone, AZ 0108
• Empirische Formel (Hill-System): C₂₄H₂₀F₄N₆O₂
• CAS-Nummer: 1825345-52-5
• Molekulargewicht: 500.45
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: -10 to -25°C
• SMILES String: FC(C1=CC=CC(C(N2[C@@H](C)CN3C(C2)=NN=C3C(F)(F)C)=O)=C1)(F)C(C4=CC=CC=C45)=NNC5=O

Beschreibung

Biochem./physiol. Wirkung

Inhibitor of Poly (ADP-ribose) polymerase PARP1, 2, and 6.

AZ0108 is an inhibitor of Poly (ADP-ribose) polymerase PARP1, 2, and 6 with approximately 100-fold selectivity against PARP3 and TNKS1. It was shown to block centrosome clustering in HeLa cells with an EC50 value of 53 nM and kill a DLBCL lymphoma cancer cell line with a GI50 value of 17 nM. AZ0108 induces replication stress in tumorigenic cells.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable