SML3608

Massonianoside B

≥95% (HPLC)

• Synonym(e): 4-[(2S,3R)-2,3-Dihydro-7-hydroxy-3-(hydroxymethyl)-5-(3-hydroxypropyl)-2-benzofuranyl]-2-methoxyphenyl 6-deoxy-α-L-mannopyranoside
• Empirische Formel (Hill-System): C₂₅H₃₂O₁₀
• CAS-Nummer: 188300-19-8
• Molekulargewicht: 492.52
• UNSPSC Code: 12352200
• NACRES: NA.21
• MDL number: MFCD20274727
• Assay: ≥95% (HPLC)
• Form: powder
• Quality level: 100

Eigenschaften

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

Cell-permeable, potent, highly selective, reversible and SAM-competitive DOT1L inhibitor

Massonianoside B is a cell-permeable, potent, highly selective, reversible and SAM-competitive DOT1L (disruptor of 4 telomeric silencing 1-like) inhibitor that decreases cellular levels of H3K79 methylation and inhibits the MLL fusion target genes HOXA9 and MEIS1 expression. Massonianoside B exhibits anti-leukemic activity. It is metabolically stable in both human and mouse liver microsomes.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable