SML3545

NVP-RXI570

≥98% (HPLC)

• Synonym(e): 1-[3-(Difluoromethyl)isothiazol-5-yl]-3-[2-fluoro-5-(hydroxymethyl)pyridin-4-yl]urea
• Empirische Formel (Hill-System): C₁₁H₉F₃N₄O₂S
• CAS-Nummer: 2270879-17-7
• Molekulargewicht: 318.27
• UNSPSC Code: 12352200
• NACRES: NA.21
• MDL number: MFCD32067923
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100

Eigenschaften

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(NC1=CC(F)=NC=C1CO)NC2=CC(C(F)F)=NS2
• InChI: 1S/C11H9F3N4O2S/c12-8-1-6(5(4-19)3-15-8)16-11(20)17-9-2-7(10(13)14)18-21-9/h1-3,10,19H,4H2,(H2,15,16,17,20)
• InChI key: CKYCAIAVJIFWPE-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

NVP-RXI570 is an orally active, potent, and selective allosteric dual inhibitor of BRM ((SMARCA2) and BRG1 (SMARCA4) that that downregulates BRM-dependent gene expression. NVP-RXI570 exhibits antiproliferative activity in a BRG1 mutant-lung-tumor xenograft model.

Orally active, potent, and selective allosteric dual inhibitor of BRM ((SMARCA2) and BRG1 (SMARCA4)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable