SML3397

SRT3025 hydrochloride

≥98% (HPLC)

• Synonym(e): 3025 HCl; 5-(3-Methoxypropyl)-2-phenyl-N-(2-(6-(pyrrolidin-1-ylmethyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)thiazole-4-carboxamide, hydrochloride salt, 5-(3-Methoxypropyl)-2-phenyl-N-[2-[6-(1-pyrrolidinylmethyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]-4-thiazolecarboxamide, hydrochloride salt, SRT 3025 HCl, SRT-3025 HCl, Sirtuin modulator 1
• Empirische Formel (Hill-System): C₃₁H₃₁N₅O₂S₂ · xHCl
• Molekulargewicht: 569.74 (free base basis)
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear (Warmed)
• Lagertemp.: -10 to -25°C
• SMILES String: O=C(C1=C(CCCOC)SC(C2=CC=CC=C2)=N1)NC3=C(C4=NC5=CC(CN6CCCC6)=CN=C5S4)C=CC=C3.[xHCl]

Beschreibung

Biochem./physiol. Wirkung

Orally active sirtuin 1 (Sirt1) activator in cultures and in vivo.

SRT3025 is an orally active sirtuin 1 activator (Sirt1 EC1.5 ≤1 μM, Emax ≥150% and <300%) that reduces cellular acetylation of Sirt1 substrates FoxO1 (induced by RANKL ) and histone 3 (1-10 μM; murine bone marrow macrophages) and exhibits in vivo efficacy in a murine atherosclerosis model (3.18 g/kg high-cholesterol diet; mice) and ovariectomy-induced bone loss in female mice (50 & 100 mg/kg via daily p.o.).

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable