SML3313

PF-07321332

≥95% (HPLC)

• Synonym(e): Nirmatrelvir, (1R,2S,5S)-N-[(1S)-1-Cyano-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-3-[(2S)-3,3-dimethyl-1-oxo-2-[(2,2,2-trifluoroacetyl)amino]butyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
• Empirische Formel (Hill-System): C₂₃H₃₂F₃N₅O₄
• CAS-Nummer: 2628280-40-8
• Molekulargewicht: 499.53
• UNSPSC Code: 12352200
• Assay: ≥95% (HPLC)
• Form: powder
• Quality level: 100

Eigenschaften

• SMILES string: O=C(N[C@H](C#N)C[C@@]1(CCNC1=O)[H])[C@H]2N(C[C@]3([C@@]2(C3(C)C)[H])[H])C([C@@H](NC(C(F)(F)F)=O)C(C)(C)C)=O
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• Quality Level: 100

Beschreibung

Biochem/physiol Actions

Nirmatrelvir is a high efficacy oral antiviral that is active against COVID-19 variants, including omicron. PF-07321332 covalently and reversibly binds to the cysteine 145 residue of the viral 3CLpro (SARS-CoV-2 main protease) catalytic domain to inhibit the SARS-CoV-2 replication cycle ( IC50 ~ 4 nM). Nirmatrelvir poorly affects cathepsin-K (IC50 = 231 nM) with no inhibition towards caspases.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable