SML3216

Melarsoprol

≥98% (HPLC)

• Synonym(e): (2-(4-(4,6-diamino-1,3,5-triazin-2-ylamino)phenyl)-1,3,2-dithiarsolan-4-yl)methanol, 2-(4-melamin-2-ylphenyl)-4-hydroxymethyl-1,3-dithia-2-arsolane, 2-p-(4,6-diamino-s-triazin-2-ylamino)phenyl-4-hydroxymethyl-1,3,2-dithiarsoline, Mel B, Melarsaprol, Melarsen B, RP 3854, p-[(4,6-diamino-s-triazin-2-yl)amino]dithiobenzenearsonous acid 3-hydroxypropylene ester
• Empirische Formel (Hill-System): C₁₂H₁₅AsN₆OS₂
• CAS-Nummer: 494-79-1
• Molekulargewicht: 398.34
• MDL-Nummer: MFCD00866803
• UNSPSC-Code: 12352107
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: NC1=NC(N)=NC(NC2=CC=C(C=C2)[As]3SCC(S3)CO)=N1
• InChI: 1S/C12H15AsN6OS2/c14-10-17-11(15)19-12(18-10)16-8-3-1-7(2-4-8)13-21-6-9(5-20)22-13/h1-4,9,20H,5-6H2,(H5,14,15,16,17,18,19)
• InChIKey: JCYZMTMYPZHVBF-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Melarsoprol is an antiprotozoal (Trypanosoma) drug used in treatment of trypanosomiasis (Chagas disease and West African sleeping sickness). The drug mechanism of action is not well characterized. Melarsoprol is still the only effective drug for chemotherapy of second stage of T. b. rhodesiense sleeping sickness. As other arsenic-containing compounds melarsoprol causes cell apoptosis of myeloma and other cancer cell lines.

Sicherheitshinweise

• Piktogramme: GHS06,GHS09
• Signalwort: Danger
• H-Sätze: H301 + H331,H410
• P-Sätze: P261 - P264 - P271 - P273 - P301 + P310 - P304 + P340 + P311
• Gefahreneinstufungen: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable