SML3028

Apostatin-1

≥98% (HPLC)

• Synonym(e): N-Cycloheptyl-?-[(4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio]-benzeneacetamide
• Empirische Formel (Hill-System): C₁₉H₂₇N₃OS
• CAS-Nummer: 2559703-06-7
• Molekulargewicht: 345.50
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(C(C1=CC=CC=C1)SC2=NCCN2C)NC3CCCCCC3
• InChI key: OXBMBNASDMMXSA-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Apostatin-1 is a cell penetrant apoptosis inhibitor that activates autophagy leading to restoration of cellular homeostasis in cells with accumulated mutant tau, α-synuclein, or huntingtin. Apostatin-1 potently and selectively inhibits TRADD. It binds to the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Apparently Apostatin-1 releases cIAP1/2 or TRAF2 from TRADD thus promoting the K63-linked ubiquitination of beclin 1.

cell penetrant apoptosis inhibitor that activates autophagy that potently and selectively inhibits TRADD

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable