SML2789

tBPC

≥98% (HPLC)

• Synonym(e): 2-[4-(1,1-Dimethylethyl)phenoxy]cyclohexanol
• Empirische Formel (Hill-System): C₁₆H₂₄O₂
• CAS-Nummer: 1942-71-8
• Molekulargewicht: 248.36
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00155433
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O(C2C(CCCC2)O)c1ccc(cc1)C(C)(C)C
• InChI: 1S/C16H24O2/c1-16(2,3)12-8-10-13(11-9-12)18-15-7-5-4-6-14(15)17/h8-11,14-15,17H,4-7H2,1-3H3
• InChI key: FTIXUILRMBSXNS-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Postitive allosteric modulator of NPY Y4 receptor

tBPC is a postitive allosteric modulator of the neuropeptide Y (NPY) Y4 receptor, which is predominantly expressed in the gastrointestinal tract and activated most strongly by pancreatic polypeptide (PP). tBPC was shown to potentiate Y4R activity in G-Protein signaling and arrestin3 recruitment and to potentiate the native PP response. tBPC was selective for Y4R over other Neuropeptide Y receptors and showed no effect on the efficacy (E_max) or potency (EC₅₀) of the NPY signal response at the Y1, Y2, or Y5 receptors at 30 μM.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3