SML2696

RSM932A

≥97% (HPLC)

• Synonym(e): 1,1′-[[1,1′-Biphenyl]-4,4′-diylbis(methylene)]bis[4-[(4-chlorophenyl)methylamino]-quinolinium dibromide (9CI), 1,1′-[[[1,1′-Biphenyl]-4,4′-diyl]bis(methylene)]bis[4-[(4-chlorophenyl)methylamino]-quinolinium] bromide, RSM 932A, TCD-717
• Empirische Formel (Hill-System): C₄₆H₃₈Cl₂N₄ · 2Br
• CAS-Nummer: 850807-63-5
• Molekulargewicht: 877.53
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥97% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• assay: ≥97% (HPLC)
• form: powder
• storage condition: desiccated
• color: faint yellow to dark orange
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CN(C1=CC=[N+](CC2=CC=C(C3=CC=C(C[N+]4=CC=C(N(C5=CC=C(Cl)C=C5)C)C6=CC=CC=C46)C=C3)C=C2)C7=CC=CC=C17)C8=CC=C(Cl)C=C8
• InChI: 1S/C46H38Cl2N4/c1-49(39-23-19-37(47)20-24-39)43-27-29-51(45-9-5-3-7-41(43)45)31-33-11-15-35(16-12-33)36-17-13-34(14-18-36)32-52-30-28-44(42-8-4-6-10-46(42)52)50(2)40-25-21-38(48)22-26-40/h3-30H,31-32H2,1-2H3/q+2
• InChI key: QGYGTMZEJNOHNU-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

RSM932A is a potent and selective choline kinase a (ChoKa, CHKA) inhibitor that induces apoptosis in cancer cells via prolonged activation of ER stress response and C/EBP homologous protein (CHOP) overproduction. RSM932A decreases de novo in phosphatidylcholine synthesis and increases ceramides levels that selectively trigger apoptosis in cancer cells. On the other hand, RSM932A induces reversible G0/G1 cell cycle arrest in nontumorigenic cells. RSM932A exhibits potent antiproliferative activity in array of human cancer cell lines.

potent and selective choline kinase a (ChoKa, CHKA) inhibitor that induces apoptosis in cancer cells

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable