This product is supplied as a powder and should be prepared as a stock solution by dissolving in DMSO at 2 mg/mL. The DMSO stock can then be diluted into the desired aqueous buffer or culture medium as needed. Higher stock concentrations may be limited by solubility and can vary by lot. This material is not sterile and should be sterile-filtered prior to use in cell culture. Please see the link below to access a Certificate of lot interest: https://www.sigmaaldrich.com/product/sigma/sml2244#product-documentation
Fortfahren mit
SML2244
AC1903
≥98% (HPLC)
Synonym(e):
N-(2-Furanylmethyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine
zur Ansicht der Organisations- und Vertragspreise.
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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
5 mg | Warenkorb auf Verfügbarkeit prüfen | € 77,20 € 65,62 |
Über diesen Artikel
Empirische Formel (Hill-System):
C19H17N3O
CAS-Nummer:
Molekulargewicht:
303.36
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
€ 65,62
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Technischer Dienst
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Unterstützung erhaltenassay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
C12=CC=CC=C1N=C(NCC3=CC=CO3)N2CC4=CC=CC=C4
InChI
1S/C19H17N3O/c1-2-7-15(8-3-1)14-22-18-11-5-4-10-17(18)21-19(22)20-13-16-9-6-12-23-16/h1-12H,13-14H2,(H,20,21)
InChI key
OECUWHDVQIITIS-UHFFFAOYSA-N
Application
AC1903 has been used as a drug candidate in a high-throughput agar colony formation assay to identify its therapeutic efficiency against medulloblastoma.[1]
Biochem/physiol Actions
AC1903 is a specific inhibitor of TRPC5, the transient receptor potential canonical channel 5, a Ca2+ permeable nonselective cation channel highly expressed in brain and kidney. AC1903 did not inhibit TRPC4 or TRPC6 currents and showed no off-target effects in kinase profiling assays. It specifically blocked TRPC5 channel activity in glomeruli of proteinuric rats, suppressed severe proteinuria, showing a therapeutic benefit in a rat model of hypertensive proteinuric kidney disease.
Chronic administration of AC1903 averts the loss of podocytes in a transgenic rat model of focal segmental glomerulosclerosis (FSGS).[2]
Specific inhibitor of TRPC5
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 20 mg/mL, clear |
| color white to beige | color white to beige | color white to beige | color , light yellow to dark orange |
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Is this compound reconstituted with bactrostatic water like a peptide?
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