TAM1 is an inhibitor of the thioesterase activity of Mycobacterium tuberculosis polyketide synthase Pks13. TAM1 binds to Pks13 TE domain. TAM1 exhibit a potent bactericidal activity against Mycobacterium Tuberculosis H37Rv strain.
inhibitor of the thioesterase activity of Mycobacterium tuberculosis polyketide synthase Pks13.
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11 - Combustible Solids
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WGK 3
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Not applicable
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Identification of new drug targets is vital for the advancement of drug discovery against Mycobacterium tuberculosis, especially given the increase of resistance worldwide to first- and second-line drugs. Because traditional target-based screening has largely proven unsuccessful for antibiotic discovery, we
Widespread resistance to first-line TB drugs is a major problem that will likely only be resolved through the development of new drugs with novel mechanisms of action. We have used structure-guided methods to develop a lead molecule that targets the
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