SML2064

LBQ657

≥97% (HPLC), neprilysin inhibitor, powder

• Synonym(e): (2R,4S)-5-(Biphenyl-4-yl)-4-((3-carboxypropionyl)amino)-2-methylpentanoic acid, Desethyl sacubitril, Sacubitrilat
• Empirische Formel (Hill-System): C₂₂H₂₅NO₅
• CAS-Nummer: 149709-44-4
• Molekulargewicht: 383.44
• NACRES: NA.77
• UNSPSC Code: 12352200
• MDL number: MFCD00921225
• Assay: ≥97% (HPLC)
• Form: powder

Eigenschaften

• Produktname: LBQ657, ≥97% (HPLC)
• assay: ≥97% (HPLC)
• form: powder
• optical activity: [α]/D -35 to -27°, c = 1 in methanol
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: OC(CCC(N[C@H](CC1=CC=C(C2=CC=CC=C2)C=C1)C[C@H](C(O)=O)C)=O)=O
• InChI: 1S/C22H25NO5/c1-15(22(27)28)13-19(23-20(24)11-12-21(25)26)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h2-10,15,19H,11-14H2,1H3,(H,23,24)(H,25,26)(H,27,28)/t15-,19+/m1/s1
• InChI key: DOBNVUFHFMVMDB-BEFAXECRSA-N

Beschreibung

Biochem/physiol Actions

Inhibitor of neprilysin (neutral endopeptidase, NEP) formed by the action of esterases on its prodrug sacubitril (AHU377)

LBQ657 is the active metabolite of sacubitril. It is an inhibitor of the enkephalinase neprilysin (neutral endopeptidase, NEP) formed by the action of esterases on its prodrug sacubitril (AHU377), which is half of the heart failure combination drug Entresto, along with the angiotensin-receptor blocker Valsartan. LBQ657 prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides.

Sicherheitshinweise

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H336,H372
• pcodes: P260 - P264 - P271 - P304 + P340 + P312 - P314 - P403 + P233
• Hazard Classifications: STOT RE 1 - STOT SE 3
• target_organs: Bone,Kidney, Central nervous system
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable