The stability of this product in solution has not been determined. However, various sources state that Lalistat 2 can be stored in DMSO at -20°C for several months. Please note that this information has not been validated internally.
Fortfahren mit
SML2053
Lalistat 2
≥98% (HPLC), lysosomal acid lipase (LAL) inhibitor, powder
Synonym(e):
1-Piperidinecarboxylic acid 4-(1-piperidinyl)-1,2,5-thiadiazol-3-yl ester, Lalistat-2
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 5 mg | Warenkorb auf Verfügbarkeit prüfen | € 109,00 | |
| 25 mg | Warenkorb auf Verfügbarkeit prüfen | € 409,00 € 347,65 |
Über diesen Artikel
Empirische Formel (Hill-System):
C13H20N4O2S
CAS-Nummer:
Molekulargewicht:
296.39
UNSPSC Code:
41106300
NACRES:
NA.77
MDL number:
Technischer Dienst
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Unterstützung erhaltenProduktname
Lalistat 2, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(N1CCCCC1)OC2=NSN=C2N3CCCCC3
InChI key
PNYYVHOTXOEBEV-UHFFFAOYSA-N
Application
Biochem/physiol Actions
Lalistat-2 is a potent and specific competitive inhibitor of the lysosomal acid lipase (LAL/Lipa). Lalistat-2 affects lipid droplets morphology and localization.
potent and specific competitive inhibitor of the lysosomal acid lipase (LAL/Lipa).
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Dieser Artikel | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 200 | Quality Level 100 | Quality Level - | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 20 mg/mL, clear |
| color white to beige | color white to beige | color white to beige | color white to beige |
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
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Chiara Pavanello et al.
Pharmacological research, 147, 104362-104362 (2019-07-23)
Lysosomal acid lipase (LAL) is responsible for the hydrolysis of cholesteryl esters (CE) and triglycerides (TG) within the lysosomes; generated cholesterol and free fatty acids (FFA) are released in the cytosol where they can regulate their own synthesis and metabolism.
Maidina Tuohetahuntila et al.
The Journal of biological chemistry, 292(30), 12436-12448 (2017-06-16)
Activation of hepatic stellate cells (HSCs) is a critical step in the development of liver fibrosis. During activation, HSCs lose their lipid droplets (LDs) containing triacylglycerols (TAGs), cholesteryl esters, and retinyl esters (REs). We previously provided evidence for the presence
Stefanie Schlager et al.
Oncotarget, 8(25), 40037-40051 (2017-04-14)
Degradation of lysosomal lipids requires lysosomal acid lipase (LAL), the only intracellular lipase known to be active at acidic pH. We found LAL to be expressed in murine immune cells with highest mRNA expression in macrophages and neutrophils. Furthermore, we
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML2053-5MG | 04061833054024 |
| SML2053-25MG | 04061833054017 |
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