SML1726

MSAB

≥95% (HPLC)

• Synonym(e): 3-[[(4-Methylphenyl)sulfonyl]amino]-benzoic acid methyl ester, Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate, WI-21
• Empirische Formel (Hill-System): C₁₅H₁₅NO₄S
• CAS-Nummer: 173436-66-3
• Molekulargewicht: 305.35
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826041
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: off-white to purple
• solubility: DMSO: 25 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CC1=CC=C(S(NC2=CC(C(OC)=O)=CC=C2)(=O)=O)C=C1
• InChI key: CVKBYFCJQSPBOI-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

A cell-permeable compound that targets β-catenin via direct affinity interaction within the C-terminal two thirds (a.a. 301-670) of the Armadillo repeat region (a.a. 136–686), inducing β-catenin ubiquitination and proteasomal degradation (Eff. conc. 1.25-5 μM in DLD-1, SW480 and LS174T cultures). MSAB selectively inhibits against Wnt sginaling-dependent proliferation of cancer cells (IC50 <6 μM), while exhibiting little efficacy in Wnt-independent cultures (<10% inhibition at 10 μM). Likewise, daily intraperitoneal injection (10-20 mg/kg/day) is efficacious in suppressing the expansion of established tumors from HCT116, HT115, and H23 xenografts in mice, while exhibiting little efficacy against the Wnt-independent H460 tumor growth.

A cellular β-catenin degradation inducer with anti-proliferation efficacy against Wnt-dependent cancer growth both in vitro and in vivo.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable