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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
25 mg | Warenkorb auf Verfügbarkeit prüfen | € 347,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C15H15Br2N3O
CAS-Nummer:
Molekulargewicht:
413.11
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Technischer Dienst
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Unterstützung erhaltenQuality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
BrC1=CC(C(C)C)=CC(Br)=C1NC(NC2=CC=CN=C2)=O
InChI
1S/C15H15Br2N3O/c1-9(2)10-6-12(16)14(13(17)7-10)20-15(21)19-11-4-3-5-18-8-11/h3-9H,1-2H3,(H2,19,20,21)
InChI key
JFNKIJKRXKPQCC-UHFFFAOYSA-N
Biochem/physiol Actions
BX430 is a selective noncompetitive allosteric antagonist of human P2X4 receptor channels.
BX430 is a selective noncompetitive allosteric antagonist of human P2X4 receptor channels. P2X4 receptors are highly expressed in the CNS, and have been studied as a therapeutic target for neuropathic pain and inflammation, and treatment of traumatic brain injury, cerebral ischemia, and spinal cord injury. BX430 is highly selective for human P2X4, with minimal activity towards other P2X subtypes, including P2X1–P2X3, P2X5, and P2X7. BX430 is also an antagonist of zebrafish P2X4 but has no effect on rat and mouse P2X4 receptors. BX430 has an IC50 value of 540 nM.
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Dieser Artikel | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. room temp | storage temp. 2-8°C |
| solubility DMSO: 20 mg/mL, clear | solubility DMSO: 15 mg/mL (clear solution) | solubility DMSO: >10 mg/mL | solubility DMSO: >30 mg/mL |
| color white to beige | color white to beige | color white to beige | color white to faint yellow |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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