SML1567

MCB-613

≥98% (HPLC)

• Synonym(e): 4-Ethyl-2,6-bis(pyridin-3-ylmethylene)cyclohexanone
• Empirische Formel (Hill-System): C₂₀H₂₀N₂O
• CAS-Nummer: 296792-62-6
• Molekulargewicht: 304.39
• NACRES: NA.77
• UNSPSC Code: 51111800
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C

Beschreibung

General description

MCB-613 (4-Ethyl-2,6-bis-pyridin-3-ylmethylene-cyclohexanone) belongs to the chalcone class of compounds.[1] It is an anti-neoplastic compound.

Application

MCB-613 has been used to study the molecular mechanism of MCB-613-induced cell death.

Biochem/physiol Actions

MCB-613 is a pan-Steroid Receptor Coactivator (SRC) stimulator. There are three steroid receptor coactivators (SRC) that interact with transcription factors and whose overexpression is assciated with a number of cancers, particularly breast cancer. MCB-613 overstimulates SRC activity in cancer cells resulting in excessive generation of reactive oxygen species (ROS), leading to cell stress and death by a process called paraptosis. MCB-613 is a cytotoxic molecule which can kill various human cancer cell lines, like HepG2 (liver), PC-3 (prostate) and MCF-7 (breast) cells.

MCB-613 is capable of inducing the transcriptional activity of steroid receptor coactivators (SRCs).[1]

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable