The long term stability of this product in aliquots has not been determined. Various sources report that stock solutions in DMSO may be stored in aliquots at -20°C to -80°C for up to 1 year.
Fortfahren mit
SML1558
Yoda1
≥98% (HPLC), powder, Piezo1 agonist
Synonym(e):
2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-pyrazine
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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
5 mg | Ab HEUTE lieferbarvonSchnelldorf | € 126,00 |
25 mg | Ab HEUTE lieferbarvonSchnelldorf | € 510,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C13H8Cl2N4S2
CAS-Nummer:
Molekulargewicht:
355.27
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Technischer Dienst
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Unterstützung erhaltenProduktname
Yoda1, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL, clear
storage temp.
2-8°C
SMILES string
[s]1c(nnc1c3nccnc3)SCc2c(cccc2Cl)Cl
InChI
1S/C13H8Cl2N4S2/c14-9-2-1-3-10(15)8(9)7-20-13-19-18-12(21-13)11-6-16-4-5-17-11/h1-6H,7H2
InChI key
BQNXBSYSQXSXPT-UHFFFAOYSA-N
General description
Yoda1 is a novel synthetic small molecule developed to study the kinetics, regulation and function of the cation channel Piezo-type mechanosensitive ion channel component 1 (Piezo1).[1]
Application
Yoda1 has been used to investigate its effect on heterotrimeric Piezo1 channels.[2]
Biochem/physiol Actions
Yoda1 is a specific activator of mouse and human cation channel Piezo1, a mechanosensitive channel that mediates Ca2+ influx on mechanical activation and has been linked to a role in blood vessel development. Yoda1 stabilizes the Piezo1 open channel. In red blood cells, this was followed by downstream activation of the KCa3.1 Gardos channel with resultant calcium influx and potassium and water efflux, causing shrinkage of the cells. Yoda1 is the first Piezo1 agonist, giving the first evidence of non-mechanical activation of a Piezo channel.
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Dieser Artikel | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level - | Quality Level 100 | Quality Level - |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 15 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear (warmed) | solubility DMSO: 2 mg/mL, clear |
| color white to beige | color white to beige | color white to light brown | color white to pink |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Are aliquots meant to be stored in 4 degrees or -20 degrees?
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