SML1537

Cantharidin Ready Made Solution

0.1 mg/mL in DMSO

• Synonym(e): 3a,7a-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione, 7a-Dimethylhexahydro-3a,4,7-epoxyisobenzofuran, Cantharidine, Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione
• Empirische Formel (Hill-System): C₁₀H₁₂O₄
• CAS-Nummer: 56-25-7
• Molekulargewicht: 196.20
• UNSPSC Code: 12352200
• EC Number: 200-664-3
• NACRES: NA.77
• Form: solution

Eigenschaften

• biological source: insect
• Quality Segment: 200
• form: solution
• concentration: 0.1 mg/mL in DMSO
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: O1[C@@H]2[C@]3([C@@]([C@H]1CC2)(C(=O)OC3=O)C)C
• InChI: 1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10-
• InChI key: DHZBEENLJMYSHQ-XCVPVQRUSA-N

Beschreibung

Biochem/physiol Actions

Cantharidin inhibits protein phosphatase 2A.

It is a component of mylabris, a traditional Chinese medicine. Cantharidin exhibits anti-tumor activity.[1] In addition, cantharidin can work against multidrug-resistant cells.[2] In the epidermis, it causes release of neutral serine proteases, leading to degeneration of the desmosmal plaque. This results in acantholysis and intraepidermal blistering as well as skin lysis.[3] PP2A is involved in the cell cycle, cell death, growth and cell-fate determination.[1]

Other Notes

Stable for at least two years at 2-8° C.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• wgk: WGK 1
• flash_point_f: 188.6 °F
• flash_point_c: 87 °C