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SML1522

Sigma-Aldrich

Doxofyllin

≥98% (HPLC)

Synonym(e):

7-(1,3-Dioxolan-2-ylmethyl)-theophyllin

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€ 122,00

€ 122,00

Voraussichtliches Versanddatum30. April 2025

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50 MG
€ 122,00

About This Item

Empirische Formel (Hill-System):
C11H14N4O4
CAS-Nummer:
69975-86-6
Molekulargewicht:
266.25
MDL-Nummer:
MFCD00865218
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329825939
NACRES:
NA.77

€ 122,00

Voraussichtliches Versanddatum30. April 2025

Bulk-Bestellung anfordern

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

H2O: 2 mg/mL, clear (warmed)

Lagertemp.

2-8°C

SMILES String

CN1C2=C(N(CC3OCCO3)C=N2)C(N(C)C1=O)=O

InChI

1S/C11H14N4O4/c1-13-9-8(10(16)14(2)11(13)17)15(6-12-9)5-7-18-3-4-19-7/h6-7H,3-5H2,1-2H3

InChIKey

HWXIGFIVGWUZAO-UHFFFAOYSA-N

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Allgemeine Beschreibung

Doxofylline is a novel xanthine derivative comprising of dioxolone group.[1][2]

Anwendung

Doxofylline has been used as a phosphodiesterase (PDE) inhibitor to study its protective effects on lipopolysaccharides (LPS)-induced inflammatory response in human pulmonary bronchial epithelial cells.[3] It has also been used to study its interaction with bovine serum albumin (BSA).[4]

Biochem./physiol. Wirkung

Doxofylline (also known as doxophylline) has antitussive and bronchodilator effects. Doxofylline is used clinically in the treatment of asthma.[5][6] Doxofylline has similar efficacy to theophylline, but unlike theophylline or other xanthines has little affinity for adenosine receptors and does not produce stimulant effects and has significantly fewer side effects.[7]
Doxofylline acts and as a non-selective phosphodiesterase (PDE) inhibitor and exhibits anti-inflammatory activity. It has the potential to treat chronic obstructive pulmonary disease (COPD).[3]

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000338920
0000338920
026M4701V

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Die Dokumentenbibliothek aufrufen

M Lazzaroni et al.
Alimentary pharmacology & therapeutics, 4(6), 643-649 (1990-12-01)
The aim of this study was to compare the effects upon gastric secretion of therapeutic doses of aminophylline, with doxofylline, a new xanthine derivative proposed for the treatment of chronic asthma. Twelve patients with endoscopically-proven healed duodenal ulcer were studied
Sokratis Katsikas et al.
Studies in health technology and informatics, 134, 113-125 (2008-04-01)
The health care sector is quickly exploiting Information and Communication Technologies towards the provision of e-health services. According to recent surveys, one of the most severe restraining factors for the proliferation of e-health is the (lack of) security measures required
C Cravanzola et al.
Drug metabolism and disposition: the biological fate of chemicals, 17(4), 437-440 (1989-07-01)
Doxofylline is a new xanthine derivative with significant bronchodilatatory activity. We have studied in HPLC the distribution of doxofylline in various areas of rat brain (cortex, cerebellum, limbic system) and its activity on the central nervous system by using a
Sami Manzoor Margay et al.
Journal of clinical and diagnostic research : JCDR, 9(4), FC05-FC08 (2015-05-30)
Asthma is a non communicable chronic disease prevalent all over the world. Two commonly used methylxanthines, theophylline and doxofylline were compared in the study in stable asthmatic patients at recommended doses by various spirometric lung function tests with forced expiratory
R Cirillo et al.
Archives internationales de pharmacodynamie et de therapie, 295, 221-237 (1988-09-01)
In the present study the interaction of doxofylline, a new antiasthmatic drug, with A1- and A2-adenosine receptors of the guinea-pig brain and rat striatum was investigated in comparison with known methylxanthine derivatives. Inhibition studies of N6-cyclohexyl-3H-adenosine (3H-CHA), 1,3-diethyl-8-3H-phenylxanthine (3H-DPX) binding
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