SML1520

GS39783

≥98% (HPLC)

• Synonym(e): GS-39783, N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine, N4,N6-dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine
• Empirische Formel (Hill-System): C₁₅H₂₃N₅O₂S
• CAS-Nummer: 39069-52-8
• Molekulargewicht: 337.44
• MDL-Nummer: MFCD06201849
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 329825937

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: faintly yellow to dark yellow
• Löslichkeit: DMSO: 5 mg/mL, clear (warmed)
• Lagertemp.: room temp
• SMILES String: CSc1nc(NC2CCCC2)c(c(NC3CCCC3)n1)[N+]([O-])=O
• InChI: 1S/C15H23N5O2S/c1-23-15-18-13(16-10-6-2-3-7-10)12(20(21)22)14(19-15)17-11-8-4-5-9-11/h10-11H,2-9H2,1H3,(H2,16,17,18,19)
• InChIKey: GSGVDKOCBKBMGG-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

GS39783 is a positive allosteric modulator (PAM) of GABA-B receptors. GABAB receptor positive allosteric modulators have potential for treatment of many neuro-psychiatric disorders as well as drug dependence and seizures. The receptor is a GPCR expressed throughout the CNS; it acts as both an auto-receptor and heteroreceptor to modulate GABA release and regulate K+ channels and Ca++ channels. GS39783 has been shown to inhibit alcohol self-administration and to have an antipsychotic-like effect in animal models of addiction and schizophrenia, respectively.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H315,H319,H335
• P-Sätze: P301 + P312 + P330 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable