SML1296

6-Thio-2′-Deoxyguanosine

≥97% (HPLC)

• Synonym(e): 2′-Ddeoxy-6-thio-guanosine, 2′-Deoxy-6-thioguanosine, 2′-Deoxythioguanosine, 2-Amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-mercaptopurine, 2-Amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purine-6(1H)-thione (7CI,8CI), 6-Thio-dG, NSC 71261
• Empirische Formel (Hill-System): C₁₀H₁₃N₅O₃S
• CAS-Nummer: 789-61-7
• Molekulargewicht: 283.31
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825770
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: powder
• Farbe: white to brown
• Löslichkeit: DMSO: 5 mg/mL, clear (warmed)
• Lagertemp.: −20°C
• SMILES String: S=C1C2=C(N([C@H]3C[C@H](O)[C@@H](CO)O3)C=N2)N=C(N)N1
• InChI: 1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5-,6-/m1/s1
• InChIKey: SCVJRXQHFJXZFZ-HSUXUTPPSA-N

Beschreibung

Anwendung

6-Thio-2′-Deoxyguanosine has been used in secreted luciferase enzyme activity in tonsillar cancer cells.

Biochem./physiol. Wirkung

6-Thio-2′-deoxyguanosine (6-thio-dG) is a nucleoside analog and telomerase substrate that is incorporated into de novo–synthesized telomeres. 6-Thio-2′-deoxyguanosine induces telomere dysfunction and rapid cell death in cancer cells, while spearing telomerase-negative cells.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable