SML0899

Windorphen

≥98% (HPLC)

• Synonym(e): (Z)-3-Chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde
• Empirische Formel (Hill-System): C₁₇H₁₅ClO₃
• CAS-Nummer: 19881-70-0
• Molekulargewicht: 302.75
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: protect from light
• Farbe: white to beige
• Löslichkeit: DMSO: 5 mg/mL, clear (warmed)
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• InChI: 1S/C17H15ClO3/c1-20-14-7-3-12(4-8-14)16(11-19)17(18)13-5-9-15(21-2)10-6-13/h3-11H,1-2H3/b17-16-
• InChIKey: VNRALGZMXHFBPG-MSUUIHNZSA-N

Beschreibung

Biochem./physiol. Wirkung

Windorphen is a selective Wnt/β-catenin signaling inhibitor acting through selective inhibition of p300, a histone acetyltransferase (HAT) that also acts as a critical coactivator of β-catenin, a transcription factor that mediates the Wnt signaling pathway involved in embryogenesis and cancer cell survival. Windorphen blocks Wnt signaling by selectively disrupting the association of p300 with the C-terminal transactivation domain of β-catenin-1. Windorphen does not inhibit the closely related CREB-binding protein (CBP). Windorphen induced apoptosis in several Wnt-dependent tumor cell lines including colon adenocarcinoma SW480and RKO and prostate cancer cell lines DU145 and PC3.

Leistungsmerkmale und Vorteile

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Sonstige Hinweise

Light sensitive

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable