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SML0868

Purmorphamine

≥98% (HPLC), powder, Hedgehog signaling activator

Synonym(e):

2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine; 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-

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Ihnen/SKUVerfügbarkeitPreis
5 mg
Warenkorb auf Verfügbarkeit prüfen
€ 161,00
25 mg
Warenkorb auf Verfügbarkeit prüfen
€ 577,00

Über diesen Artikel

Empirische Formel (Hill-System):
C31H32N6O2
CAS-Nummer:
Molekulargewicht:
520.62
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

€ 161,00


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Produktname

Purmorphamine, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

N7(CCOCC7)c1ccc(cc1)Nc2nc(nc5[n](cnc52)C6CCCCC6)Oc3c4c(ccc3)cccc4

InChI

1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)

InChI key

FYBHCRQFSFYWPY-UHFFFAOYSA-N

Application

Purmorphamine has been used to study the consequences of upregulation of Hedgehog signalling pathway in Tupfel long fin strain Zebrafish.

Biochem/physiol Actions

Purmorphamine activates the Hedgehog (Hh) signaling pathway, directly binding to the Smoothened (Smo) receptor.
Purmorphamine activates the Hedgehog (Hh) signaling pathway, directly binding to the Smoothened (Smo) receptor. In various studies, purmorphamine has been shown to induce osteoblast differentiation, generate cardiomyocytes from human embryonic stem cells, increase the neuronal differentiation of a human striatal neural stem cell line, and to differentiate human umbilical cord mesenchymal stem cells (hUCMSCs) into motoneurons.

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Dieser Artikel
SML0633SML1257SML1544
assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: 1 mg/mL, clear (warmed)

solubility

DMSO: 20 mg/mL, clear

color

white to beige

color

white to beige

color

white to light brown

color

white to beige


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pictograms

Health hazard

signalword

Warning

hcodes

Hazard Classifications

Muta. 2

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Questions

  1. What is the stability of purmorphamine as solid and in solution of DMSO ?

    1 answer
    1. This product is not assigned an expiration date or retest schedule. Products that are robust and extremely stable in their original unopened container are not assigned an expiration date or retest schedule. These products will not have dating reported on either the label or the Certificate of Analysis. Products without an expiration or retest date are covered by a warranty period of 1 year from the date of product shipment. Full product dating information can be reviewed at the following link: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/190/408/product-dating-information-ms.pdf. Stability in solution has not been internally validated. Other sources recommend storing at -20°C and using it within 1 year. It is advised to aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

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