SML0618

NSC697923

≥98% (HPLC)

• Synonym(e): 2-Nitro-5-tosylfuran, 2-[(4-Methylphenyl)sulfonyl]-5-nitro-Furan
• Empirische Formel (Hill-System): C₁₁H₉NO₅S
• CAS-Nummer: 343351-67-7
• Molekulargewicht: 267.26
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: [S](=O)(=O)(c2[o]c(cc2)[N+](=O)[O-])c1ccc(cc1)C
• InChI: 1S/C11H9NO5S/c1-8-2-4-9(5-3-8)18(15,16)11-7-6-10(17-11)12(13)14/h2-7H,1H3
• InChI key: GAUHIPWCDXOLCZ-UHFFFAOYSA-N

Beschreibung

General description

NSC697923 stimulates apoptosis in p53 mutant neuroblastoma (NB) cells by triggering JNK (c-Jun N-terminal kinases) pathway. This ubiquitin-conjugating enzyme E2 N (UBE2N) inhibitor is considered as an important treatment option for neuroblastoma (NB) patients. NSC697923 prevents the multiplication and survival of diffuse large B-cell lymphoma (DLBCL) cells in vitro.[1]

Application

NSC697923 has been used as an inhibitor in STING-dependent NF-κB (nuclear factor-κB) activation after DNA damage, mediated by TRAF6 (TNF receptor-associated factor 6).

Biochem/physiol Actions

NSC697923 is a cell-permeable and selective inhibitor of the ubiquitin-conjugating (E2) enzyme Ubc13-Uev1A that blocks the formation of the Ubc13 - ubiquitin thioester conjugate, and suppresses constitutive NF-kB activity in ABC-DLBCL cells. Also, NSC697923 inhibits the proliferation and survival of ABC-DLBCL and GCB-DLBCL cancer cells.

NSC697923 is a cell-permeable and selective inhibitor of the ubiquitin-conjugating (E2) enzyme Ubc13-Uev1A.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3