SML0593

CGP52432

≥98% (HPLC)

• Synonym(e): [3-[[(3,4-Dichlorophenyl)methyl]amino]propyl](diethoxymethyl)-phosphinic acid
• Empirische Formel (Hill-System): C₁₅H₂₄Cl₂NO₄P
• CAS-Nummer: 139667-74-6
• Molekulargewicht: 384.24
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 1 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: [P](=O)(O)(C(OCC)OCC)CCCNCc1cc(c(cc1)Cl)Cl
• InChI: 1S/C15H24Cl2NO4P/c1-3-21-15(22-4-2)23(19,20)9-5-8-18-11-12-6-7-13(16)14(17)10-12/h6-7,10,15,18H,3-5,8-9,11H2,1-2H3,(H,19,20)
• InChI key: GJZVQXWEIYRHBE-UHFFFAOYSA-N

Beschreibung

Application

CGP52432 has been used as a γ-aminobutyric acid B (GABA_B) antagonist:

• to study its effects on the simulation of the onset of status epilepticus (SE) in mice[1]
• for voltage-clamp recording in mice neurons[2]
• to study its effects on the GABA_B receptor-mediated neurotransmission in guinea pig hippocampus[3]

Biochem/physiol Actions

CGP52432 is a very potent antagonist of GABA_B receptors.

CGP52432 is a very potent antagonist of GABA_B receptors. (IC₅₀ = 85 nM).

CGP52432 participates in inhibiting the glycine overflow in the hippocampus.[4]

Features and Benefits

This compound is featured on the GABAB Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Do not freeze.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable