SML0537

MI-1

≥98% (HPLC)

• Synonym(e): 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-5,6,7,8-tetrahydro-[1]benzothieno[2,3-d]pyrimidine, CCG21397
• Empirische Formel (Hill-System): C₁₉H₂₅N₅S₂
• CAS-Nummer: 433311-07-0
• Molekulargewicht: 387.57
• MDL-Nummer: MFCD03268791
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 329825540
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 15 mg/mL (clear solution, warmed)
• Lagertemp.: 2-8°C
• SMILES String: CC1(C)CN=C(S1)N2CCN(CC2)c3ncnc4sc5CCCCc5c34
• InChI: 1S/C19H25N5S2/c1-19(2)11-20-18(26-19)24-9-7-23(8-10-24)16-15-13-5-3-4-6-14(13)25-17(15)22-12-21-16/h12H,3-11H2,1-2H3
• InChIKey: MNSXQGKLDTVOLP-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

MI-1 is a Menin-MLL interaction inhibitor. The mixed lineage leukemia (MLL) gene encodes MLL, a histone methyltransferase important in regulating gene transcription. MLL rearrangements and formation of fusion oncoproteins can block hematopoietic differentiation and increase proliferation, resulting in acute leukemias. Menin, encoded by the MEN1 gene, is a tumor suppressor associated with multiple endocrine neoplasia type 1. It also acts as an oncogenic co-factor of MLL fusion proteins. MI-1 inhibits Menin-MLL interaction with an IC₅₀ of 1.9 micromolar.

MI-1is a Menin-MLL interaction inhibitor.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable