SML0364

RAD51 Inhibitor B02

≥98% (HPLC), RAD51 recombinase inhibitor, powder

• Synonym(e): 3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone
• Empirische Formel (Hill-System): C₂₂H₁₇N₃O
• CAS-Nummer: 1290541-46-6
• Molekulargewicht: 339.39
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825366
• NACRES: NA.77
• MDL number: MFCD03294274
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: RAD51 Inhibitor B02, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to dark brown
• solubility: DMSO: ≥5 mg/mL
• storage temp.: 2-8°C
• SMILES string: O=C1N(CC2=CC=CC=C2)C(/C=C/C3=CN=CC=C3)=NC4=C1C=CC=C4
• InChI: 1S/C22H17N3O/c26-22-19-10-4-5-11-20(19)24-21(13-12-17-9-6-14-23-15-17)25(22)16-18-7-2-1-3-8-18/h1-15H,16H2/b13-12+
• InChI key: GEKDQXSPTHHANP-OUKQBFOZSA-N

Beschreibung

Application

RAD51 Inhibitor B02 has been used:

• to test its effect on the polar body extrusion (PBE) rate in porcine oocytes
• for RAD51 inhibition in porcine embryos
• as RAD51 inhibitor and to test its effect on targeted nucleotide substitution (TNS) in induced pluripotent stem cells (iPSCs)

Biochem/physiol Actions

B02 (3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone), a pyridinylvinyl-quinazolinone compound is cell-permeable. B02 inhibits human RAD51 recombinase and subsequent nucleofilaments formation. It halts homologous recombination (HR) repair events in cancer cells. B02 favors apoptosis in multiple myeloma and is crucial for sensitizing them to doxorubicin.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable