SML0326

GTS-21

≥97% (HPLC), α7 Nicotinic Acetylcholine Receptor Agonist, powder

• Synonym(e): 3-(2,4-Dimethoxybenzylidene)-anabaseine dihydrochloride, DMBX-anabaseine, DMXB, DMXB-A, GTS21
• Empirische Formel (Hill-System): C₁₉H₂₀N₂O₂ · 2HCl
• CAS-Nummer: 156223-05-1
• Molekulargewicht: 381.30
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825331
• NACRES: NA.77
• MDL number: MFCD00941364
• Assay: ≥97% (HPLC)
• Form: powder

Eigenschaften

• Produktname: GTS-21, ≥97% (HPLC)
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• color: faintly yellow to dark yellow
• solubility: H₂O: >5 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.Cl.COc1ccc(\C=C2/CCCN=C2c3cccnc3)c(OC)c1
• InChI: 1S/C19H20N2O2.2ClH/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16;;/h3,6-9,11-13H,4-5,10H2,1-2H3;2*1H/b15-11+;;
• InChI key: BXKYFUGAAFLYJL-BXGYHSFXSA-N

Beschreibung

Application

GTS-21 has been used:

• as an α7 nicotinic acetylcholine receptors (nAChR) partial agonist to elucidate its anti-inflammatory effects in mouse macrophages[1]
• to test its protective effect on the renal injury induced by lipopolysaccharide (LPS)[2]
• to test its effect on microvascular inflammation in endotoxemia induced by LPS[3]

Biochem/physiol Actions

GTS-2, a derivative of anisine[3] is an immunomodulatory drug. It is used for treating pancreatitis and septicemia.[2] GTS-2 inhibits the pro-inflammatory cytokines especially the interleukin-6 (IL6) and tumor necrosis factor (TNF) in sepsis and endotoxemia.[1]

GTS-21 is a selective agonist at α-7 nicotinic receptors with anti-inflammatory and cognition enhancing activities. GTS-21 has also been investigated for the treatment of schizophrenia.

GTS-21 is a selective agonist at α-7 nicotinic receptors.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable