SML0271

VER-155008

≥98% (HPLC), Hsp70 inhibitor, powder

• Synonym(e): 5′-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
• Empirische Formel (Hill-System): C₂₅H₂₃Cl₂N₇O₄
• CAS-Nummer: 1134156-31-2
• Molekulargewicht: 556.40
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825279
• NACRES: NA.77
• MDL number: MFCD18086892
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Produktname: VER-155008, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to light brown
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Nc1ncnc2n([C@@H]3O[C@H](COCc4ccc(cc4)C#N)[C@@H](O)[C@H]3O)c(NCc5ccc(Cl)c(Cl)c5)nc12
• InChI: 1S/C25H23Cl2N7O4/c26-16-6-5-15(7-17(16)27)9-30-25-33-19-22(29)31-12-32-23(19)34(25)24-21(36)20(35)18(38-24)11-37-10-14-3-1-13(8-28)2-4-14/h1-7,12,18,20-21,24,35-36H,9-11H2,(H,30,33)(H2,29,31,32)/t18-,20-,21-,24-/m1/s1
• InChI key: ZXGGCBQORXDVTE-UMCMBGNQSA-N

Beschreibung

Application

VER-155008 has been used as a heat shock protein 70 (HSP70) inhibitor:

• to study its effects on human embryonic kidney 293 (HEK293T) cells[1]
• to study its effects on viral mRNA synthesis and protein expression in Vero E6 cells[2]
• to determine its effects on the attenuation of seizures in rats[3]

Biochem/physiol Actions

VER-155002 is a Hsp70 inhibitor.

VER-155002 is a small molecule, ATP-derivative inhibitor of HSP70 (IC₅₀ = 500 nM). The compound inhibits proliferation of several colon and breast cancer cell lines, induces caspase dependent apoptosis in BT474 cells and down regulates expression of Her2 and Raf-1 in HCT116 cells.

VER‐155008 positively promotes memory recovery and axonal regrowth.[4] It is also involved in inhibiting cell cycle progression and proliferation in non-small-cell lung cancer (NSCLC).[5]

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable