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SML0261

Sigma-Aldrich

SC66

≥98% (HPLC)

Synonym(e):

(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone

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About This Item

Empirische Formel (Hill-System):
C18H16N2O
CAS-Nummer:
871361-88-5
Molekulargewicht:
276.33
MDL-Nummer:
MFCD05025493
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329825269

Assay

≥98% (HPLC)

Form

powder

Farbe

faintly yellow to dark yellow

Löslichkeit

DMSO: ≥5 mg/mL (warmed)

Lagertemp.

2-8°C

SMILES String

O=C1\C(CCC\C1=C/c2ccncc2)=C\c3ccncc3

InChI

1S/C18H16N2O/c21-18-16(12-14-4-8-19-9-5-14)2-1-3-17(18)13-15-6-10-20-11-7-15/h4-13H,1-3H2/b16-12+,17-13+

InChIKey

CYVVJSKZRBZHAV-UNZYHPAISA-N

Biochem./physiol. Wirkung

SC66 is a dual function Akt inhibitor.
SC66 is an allosteric inhibitor of Akt that prevents binding of PIP3 to the PH domain. The compound prevents activation of Akt by PIP3, and also facilitates ubiquination and degradation of Akt. SC66 inhibition is maintained against a cancer relevant Akt mutation (E17K) that is resistant to the actions of PIP3K inhibitors. SC66 is active in vivo, and significantly inhibits the ability of HEK293T cells to form colonies in soft agar and tumor growth in nude mice.

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number
022M4608V

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Protokolle

PKB/Akt

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