SML0206

EAA-090

≥98% (HPLC)

• Synonym(e): P-[2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethyl]-phosphonic acid, WAY-126090
• Empirische Formel (Hill-System): C₉H₁₃N₂O₅P
• CAS-Nummer: 144912-63-0
• Molekulargewicht: 260.18
• MDL-Nummer: MFCD00912427
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825228

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: light yellow to yellow
• Löslichkeit: H₂O: ≥2 mg/mL
• Ersteller: Wyeth
• Lagertemp.: 2-8°C
• SMILES String: OP(O)(=O)CCN1CCCNC2=C1C(=O)C2=O
• InChI: 1S/C9H13N2O5P/c12-8-6-7(9(8)13)11(3-1-2-10-6)4-5-17(14,15)16/h10H,1-5H2,(H2,14,15,16)
• InChIKey: BDABGOLMYNHHTR-UHFFFAOYSA-N

Beschreibung

Anwendung

EAA-090 was used to study the role of glutamate receptor-mediated signaling in the formation of filipodia and secondary dendrites in rat hippocampal neurons.

Biochem./physiol. Wirkung

EAA-090 inhibits the binding of ligands to glutamate receptors and blocks NMDA-induced currents. It is neuroprotective against glutamate and ischemia-induced toxicity.

EAA-090 is a potent NMDA receptor antagonist with neuroprotective properties. In isoflurane-anesthetized dogs, EAA-090 reduces the minimum alveolar concentration (MAC) of isoflurane and increases systolic, mean, and diastolic arterial blood pressure.

Leistungsmerkmale und Vorteile

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H300
• P-Sätze: P264 - P301 + P310
• Gefahreneinstufungen: Acute Tox. 2 Oral
• Lagerklassenschlüssel: 6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable