Product SML0031, DBeQ, is soluble to 100 mM with DMSO and to 20 mM with ethanol.
Fortfahren mit
SML0031
DBeQ
≥98% (HPLC)
Synonym(e):
JRF 12, N2,N4-dibenzylquinazoline-2,4-diamine
Anmelden zur Ansicht der Organisations- und Vertragspreise.
Größe auswählen
Ansicht ändern
| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
5 mg | Warenkorb auf Verfügbarkeit prüfen | € 107,00 |
25 mg | Warenkorb auf Verfügbarkeit prüfen | € 435,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C22H20N4
CAS-Nummer:
Molekulargewicht:
340.42
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Technischer Dienst
Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.
Unterstützung erhaltenQuality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: ≥20 mg/mL
storage temp.
room temp
SMILES string
C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4
InChI
1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)
InChI key
QAIMUUJJAJBPCL-UHFFFAOYSA-N
Application
HeLa cells were treated with DBeQ and the effects on in vivo ubiquitination and protein dislocation were studied by live cell imaging.[1]
Biochem/physiol Actions
ATPase p97 inhibitor.
DBeQ is a potent and specific inhibitor of ATPase p97, an integral component of the ubiquitin-fusion degradation (UFD) pathway. DBeQ inhibits the degradation of ubiquitinated proteins, the endoplasmic reticulum-associated degradation pathway, and autophagosome maturation. The compound also potently inhibits cellular proliferation and induces caspase 3/7 activity and apoptosis.
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level 100 |
| storage temp. room temp | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: ≥20 mg/mL | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear (warmed) | solubility DMSO: 20 mg/mL, clear |
| color white to beige | color white to beige | color white to beige | color white to beige |
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
Hier finden Sie alle aktuellen Versionen:
Besitzen Sie dieses Produkt bereits?
In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
-
What is the solubility of Product SML0031, DBeQ?
1 answer-
Helpful?
-
-
What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
-