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SCP0148
Furin Inhibitor II Peptide
≥95% (HPLC), lyophilized powder
Synonym(e):
Hexa-D-arginine amide
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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
5 mg | Versand in der Regel in 2 Wochen. | € 282,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C36H75N25O6
Molekulargewicht:
954.14
UNSPSC Code:
12352202
NACRES:
NA.32
€ 282,00
Versand in der Regel in 2 Wochen.
Technischer Dienst
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Unterstützung erhaltenProduktname
Furin Inhibitor II,
assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥48%
storage condition
protect from light
technique(s)
protein extraction: suitable
input
mammalian sample(s)
storage temp.
−20°C
General description
Furin is a calcium-dependent serine endoproteinase and belongs to the subtilisin-like proprotein/prohormone convertase (PC) family. It is distributed ubiquitously and has a rhythmic movement between the trans-Golgi network, cell surface and the endosomes.
Application
Furin Inhibitor II has been used as a furin inhibitor:
- to study its effects on transforming growth factor β1 (TGF-β1) induced glial cell line-derived neurotrophic factor (GDNF) production in non-tumorigenic immortalized human granulosa cell line (SVOG).
- to study its effect on cleavage of (Pro) renin receptor (PRR) induced by bovine serum albumin (BSA) in human kidney 2 (HK-2) cells.
- in furin cleavage assay.
Biochem/physiol Actions
Furin plays a role in processing several pro-proteins such as, bone morphogenetic protein 4 (BMP-4), insulin receptor and Notch1 receptor. It also processes human immune deficiency virus 1 (HIV-1) glycoprotein gp160, several metalloproteases and pro-β-nerve growth (pro-β-NGF) factor. Furin is also involved in cleaving transforming growth factor β1 (TGF-β1).
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Dieser Artikel | |||
|---|---|---|---|
| description - | description recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE) | description Furin Inhibitor I, is a peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity. | description A fluorogenic substrate for furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km ~ 2 x 10⁴ s⁻¹M⁻¹). |
| assay ≥95% (HPLC) | assay ≥95% (SDS-PAGE) | assay ≥90% (HPLC) | assay ≥95% (HPLC) |
| technique(s) protein extraction: suitable | technique(s) - | technique(s) - | technique(s) - |
| form lyophilized | form lyophilized powder | form solid | form solid |
| storage condition protect from light | storage condition - | storage condition OK to freeze, desiccated | storage condition OK to freeze, desiccated (hygroscopic), protect from light |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| composition Peptide Content, ≥48% | composition - | composition - | composition - |
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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How can Product SCP0148, Furin Inhibitor II be dissolved?
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Product SCP0148, Furin Inhibitor II, is soluble in water at a concentration of 1 mg/mL.
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How can product SCP0148, Furin Inhibitor II, be dissolved?
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Product SCP0148, Furin Inhibitor II is soluble in water at 1 mg/ml.
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