SAB5702787

Anti-Phospho-RB(pSer780) Antibody, clone 8R5F5, Rabbit Monoclonal

• Synonym(e): OSRC,PPP1R130,RB,p105-Rb,pRb,pp110,RB1,Rb
• UNSPSC-Code: 12352203
• NACRES: NA.46

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Materialien: colorless
• Klon: 8R5F5, monoclonal
• Form: liquid
• Mol-Gew.: 106 kDa
• Speziesreaktivität: rat, human, rat
• Konzentration: 1.74 mg/mL
• Methode(n): immunohistochemistry: 1:50 - 1:200; western blot: 1:500 - 1:2000
• Farbe: colorless
• Isotyp: IgG
• Immunogene Sequenz: TLSPI
• UniProt-Hinterlegungsnummer: P06400
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... RB1(5925)

Beschreibung

Allgemeine Beschreibung

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]

Immunogen

A synthetic phosphorylated peptide around S780 of human RB (P06400).

PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.

Anwendung

WB, IHC

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H317,H411
• P-Sätze: P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
• Gefahreneinstufungen: Aquatic Chronic 2 - Skin Sens. 1
• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3