SAB5500153

Anti-N-RAS antibody, Rabbit monoclonal

recombinant, expressed in proprietary host, clone SP174, affinity isolated antibody

• Synonym(e): Anti-ALPS4, Anti-CMNS, Anti-KRAS, Anti-N-ras, Anti-NCMS, Anti-NRAS1, Anti-NS6
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Rekombinant: expressed in proprietary host
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: SP174, monoclonal
• Speziesreaktivität: human (tested)
• Methode(n): immunoblotting: 1:400; immunohistochemistry: 1:100
• Isotyp: IgG
• UniProt-Hinterlegungsnummer: P01111
• Versandbedingung: wet ice
• Lagertemp.: 2-8°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... NRAS(4893)

Beschreibung

Allgemeine Beschreibung

GTPase N-Ras or N-Ras is a guanine-nucleotide binding protein. Receptor tyrosine kinases and G-protein-coupled receptors activate Ras, which then stimulates the MAPK signal pathway. Point mutations (Q61R) in Ras prevent the GAP-mediated inhibition of the MAPK pathway in certain cancers such as lung carcinoma and melanoma. Abnormal MAPK signaling may lead to uncontrolled cell proliferation, resistance to both apoptosis and cancer therapy.

Immunogen

Synthetic peptide of human N-Ras protein containing N-Ras (Q61R) point mutation.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable