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SAB4503568

Sigma-Aldrich

Anti-EXO1 antibody produced in rabbit

affinity isolated antibody

Synonym(e):

EXO1, Exonuclease 1, Exonuclease I, hExo1, hExoI

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 94 kDa

Speziesreaktivität

human, mouse

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

Q9UQ84

UniProt-Hinterlegungsnummer

Q9UQ84

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... EXO1(9156)

Allgemeine Beschreibung

Anti-EXO1 Antibody detects endogenous levels of total EXO1 protein.
Exonuclease 1 (EXO1), a member of RAD2 nuclease family, comprises an amino-terminal (N) domain, intermediate spacer region and an internal (I) domain with cysteine and glutamate residues. The Exo 1 gene is mapped to human chromosome 1q43.

Immunogen

The antiserum was produced against synthesized peptide derived from human EXO1.

Immunogen Range: 61-110

Anwendung

Anti-EXO1 antibody produced in rabbit has been used in immunoblotting.

Biochem./physiol. Wirkung

Exonuclease 1 (EXO1) N-domain mediates the DNA binding and the I domain is crucial for magnesium binding. It displays micro-mediated end-joining, 5′ to 3′ exonuclease activity and mediates homologous recombination and replication. EXO1 is more efficient on single-stranded DNA (ssDNA) than double-stranded DNA in exonucleolytic degradation. It also exhibits 5′ ssDNA-flap-specific endonuclease activity. EXO1 polymorphisms may be implicated in epithelial ovarian cancer (EOC).

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Human exonuclease 1 (EXO1) activity characterization and its function on flap structures.
Keijzers, et al.
Bioscience Reports, 35 (2018)
Tingyan Shi et al.
OncoTargets and therapy, 10, 4841-4851 (2017-10-19)
Exonuclease 1 (EXO1), one of DNA mismatch repair pathway genes, functions in maintaining genomic stability and affects tumor progression. We hypothesized that genetic variations in EXO1 may predict clinical outcomes in epithelial ovarian cancer (EOC). In this cohort study with
Eugene Izumchenko et al.
DNA repair, 11(12), 951-964 (2012-10-16)
S(N)1 DNA methylating agents are genotoxic agents that methylate numerous nucleophilic centers within DNA including the O(6) position of guanine (O(6)meG). Methylation of this extracyclic oxygen forces mispairing with thymine during DNA replication. The mismatch repair (MMR) system recognizes these
Mahmoud El-Shemerly et al.
Nucleic acids research, 36(2), 511-519 (2007-12-01)
Nucleases play important roles in DNA synthesis, recombination and repair. We have previously shown that human exonuclease 1 (hEXO1) is phosphorylated in response to agents stalling DNA replication and that hEXO1 consequently undergoes ubiquitination and degradation in a proteasome-dependent manner.
Mu-Yan Cai et al.
Cell reports, 30(7), 2402-2415 (2020-02-23)
Cells deficient in ataxia telangiectasia mutated (ATM) are hypersensitive to ionizing radiation and other anti-cancer agents that induce double-strand DNA breaks. ATM inhibitors may therefore sensitize cancer cells to these agents. Some cancers may also have underlying genetic defects predisposing

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