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Merck

SAB4501145

Sigma-Aldrich

Anti-LATS1 antibody produced in rabbit

affinity isolated antibody

Synonym(e):

Kinase phosphorylated during mitosis protein, Large tumor suppressor homolog 1, Serine/threonine-protein kinase kpm, WARTS protein kinase, h-warts/ Large tumor suppressor homolog 2

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 126 kDa

Speziesreaktivität

human, mouse

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:40000
immunohistochemistry: 1:50-1:100

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... LATS1(9113)

Allgemeine Beschreibung

Anti-LATS1 Antibody detects endogenous levels of total LATS1 protein.
The LATS1 (large tumor suppressor kinase 1) gene encodes a serine/threonine kinase and is located on human chromosome 6q24-25. It is present in the mitotic apparatus. It is also called as WARTS.

Immunogen

The antiserum was produced against synthesized peptide derived from human LATS1/2.

Immunogen Range: 1041-1090

Biochem./physiol. Wirkung

The LATS1 (large tumor suppressor kinase 1) protein repress the multiplication and invasion of cervical cancer. It acts as a cell cycle inhibitor. Low level expression of LATS1 is associated with the progression and prognosis of glioma. It is a tumor suppressor gene, thereby it participates in various mitotic processes.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

LATS1 suppresses proliferation and invasion of cervical cancer
Deng J, et al.
Molecular Medicine Reports, 15(4), 1654-1660 (2017)
Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation
Wierzbicki PM, et al.
World Journal of Gastroenterology, 19(27), 4363-4373 (2013)
Decreased expression of LATS1 is correlated with the progression and prognosis of glioma
Ji T, et al.
Journal of Experimental & Clinical Cancer Research (2012)
Di Li et al.
CNS neuroscience & therapeutics, 24(10), 906-916 (2018-03-01)
To investigate the roles of Lats1/p-YAP1 pathway in TBI-induced neuronal apoptosis and neurological deficits in rats. We found that Lats1 and YAP1 were expressed in cerebral cortex neurons of Sprague-Dawley rats, and the phosphorylation levels of Lats1 and YAP1 in

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