SAB4300028

Anti-phospho-MEF2A (pThr³¹²) antibody produced in rabbit

affinity isolated antibody

• Synonym(e): Anti-ADCAD1 antibody produced in rabbit, Anti-RSRFC4 antibody produced in rabbit, Anti-RSRFC9 antibody produced in rabbit, Anti-myocyte enhancer factor 2A antibody produced in rabbit
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: ~54 kDa
• Speziesreaktivität: human, rat, mouse
• Konzentration: 1 mg/mL
• Methode(n): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200
• Isotyp: IgG
• Immunogene Sequenz: (L-A-TP-P-V)
• NCBI-Hinterlegungsnummer: NP_001124398.1
• UniProt-Hinterlegungsnummer: Q02078
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: phosphorylation (pThr312)
• Angaben zum Gen: human ... MEF2A(4205)

Beschreibung

Immunogen

Peptide sequence around phosphorylation site of threonine 312 (L-A-T(p)-P-V), according to the protein MEF2A.

Leistungsmerkmale und Vorteile

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Zielbeschreibung

The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are one class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes 'agamous' and 'deficiens' and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain.

Physikalische Form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable