SAB4200030

Anti-HOXD9 (Internal Region) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(e): Anti-HOX4C, Anti-Homeobox D9, Anti-Hox-4.3
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~40 kDa
• Speziesreaktivität: human
• Verpackung: antibody small pack of 25 μL
• Konzentration: ~1.0 mg/mL
• Methode(n): immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells over expressing human HOXD9; indirect immunofluorescence: 2-5 μg/mL using paraformaldehyde fixed HEK-293T cells over expressing human HOXD9; western blot: 1-2 μg/mL using lysates of HEK-293T cells over expressing human HOXD9
• UniProt-Hinterlegungsnummer: P28356
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... HOXD9(3235) ; mouse ... Hoxd9(15438) ; rat ... Hoxd9(688999)

Beschreibung

Allgemeine Beschreibung

There are 39 homeobox (HOX) genes in vertebrates. They are divided into four clusters (HOXA−HOXD), located on different chromosomes (7p15, 17q21.2, 12q13 and 2q31). Each cluster contains 9−11 member genes encoding relatively small gene products containing a highly conserved 60-amino-acid region (the homeobox), with DNA-binding activity that contributes to their activity as transcription factors. The HOX genes are evolutionarily conserved.

Anwendung

Anti-HOXD9 (Internal Region) antibody produced in rabbit has been used in:

• immunoblotting
• immunoprecipitation
• immunofluorescence

Biochem./physiol. Wirkung

Homeobox (HOX) transcription factors control important development pathways involved embryo morphogenesis. HOX genes mainly participate in the formation of the body plan during embryonic development. Altered homeobox gene function or expression is implicated in the development of cancers such as leukemias or neoplasms of the breast, prostate, kidney, colon, skin, and brain. HOXD9 is involved in patterning of forelimb, axial skeleton and embryonic segmentation. It might promote cell migration, invasion and metastasis in hepatocellular carcinoma. HOXD9 was shown to be involved in the early stages of normal joint development and also in the pathologic process of arthritis.

Physikalische Form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable