SAB1409054

Monoclonal Anti-FTL antibody produced in mouse

clone X1, purified immunoglobulin, buffered aqueous solution

• Synonym(e): MGC71996
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: X1, monoclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 44.99 kDa
• Speziesreaktivität: human
• Methode(n): immunoprecipitation (IP): suitable; indirect ELISA: suitable; indirect immunofluorescence: suitable; western blot: 1-5 μg/mL
• Isotyp: IgG1κ
• NCBI-Hinterlegungsnummer: BC004245
• UniProt-Hinterlegungsnummer: P02792
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... FTL(2512)

Beschreibung

Allgemeine Beschreibung

Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. This gene encodes the light subunit of the ferritin protein. It is composed of 24 subunits of the heavy and light ferritin chains.(provided by RefSeq). In humans, the heavy H and the light L chains are made up of 183 and 175 amino acids, respectively. FTL (ferritin) is a heteropolymer, located on human chromosome 19q13. Ferritins centralize iron in their inner compartment as a bioavailable iron oxide biomineral.

Immunogen

FTL (AAH04245, 1 a.a. ~ 175 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MSSQIRQNYSTDVEAAVNSLVNLYLQASYTYLSLGFYFDRDDVALEGVSHFFRELAEEKREGYERLLKMQNQRGGRALFQDIKKPAEDEWGKTPDAMKAAMALEKKLNQALLDLHALGSARTDPHLCDFLETHFLDEEVKLIKKMGDHLTNLHRLGGPEAGLGEYLFERLTLKHD

Biochem./physiol. Wirkung

Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes.
L-Ferritin subunits deliver the scaffold for a trinuclear peroxo-bridged cluster.

Physikalische Form

Solution in phosphate buffered saline, pH 7.4

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable