S9947

Monoclonal Anti-Sonic Hedgehog Peptide (C-terminal) antibody produced in rat

clone 55626, purified immunoglobulin, lyophilized powder

• Synonym(e): Anti-Dsh, Anti-Hhg1, Anti-Hx, Anti-Shh
• NACRES: NA.41
• UNSPSC Code: 51111800
• Conjugate: unconjugated
• Clone: 55626, monoclonal
• Application: WB
• Citations: 4

Eigenschaften

• biological source: rat
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 55626, monoclonal
• form: lyophilized powder
• species reactivity: mouse
• technique(s): western blot: 1-2 μg/mL
• isotype: IgG2a
• UniProt accession no.: Q62226
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: mouse ... Shh(20423)

Beschreibung

Immunogen

purified, E. coli-derived recombinant mouse 6× histidine-tagged sonic hedgehog C-terminal peptide (aa 199-437).

Biochem/physiol Actions

Shh protein is secreted by Purkinje cells in the cerebellum with both autocrine and paracrine functions. The Shh signaling is mediated by the interaction of Shh with transmembrane proteins, Patched and Smoothened. The Shh pathway cross-talks Notch and Wnt pathways and acts via downstream targets such as cyclins, gamma catenin, myc and other transcription factors. The Hh family members have multiple roles as morphogens, cell survival factors, setting anterior-posterior axis and digit formation during development of limb, and axon guidance factors during the development of brain and nervous system.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 13 - Non Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)