S8692

Sulproston

≥95% (HPLC), oil

• Synonym(e): (5Z,11α,13E,15R)--11,15-Dihydroxy-9-oxo-16-phenoxy-17,18,19,20-tetranorprosta-5,13-dienoic acid methane sulfonamide, CP-34089, SHB-286, ZK-57671
• Empirische Formel (Hill-System): C₂₃H₃₁NO₇S
• CAS-Nummer: 60325-46-4
• Molekulargewicht: 465.56
• EG-Nummer: 262-173-0
• MDL-Nummer: MFCD00216056
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724621
• NACRES: NA.77

Eigenschaften

• Assay: ≥95% (HPLC)
• Form: oil
• Farbe: colorless to yellow-brown
• Löslichkeit: DMSO: >10 mg/mL
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• SMILES String: CS(=O)(=O)NC(=O)CCC\C=C/C[C@@H]1[C@@H](\C=C\[C@@H](O)COc2ccccc2)[C@H](O)CC1=O
• InChI: 1S/C23H31NO7S/c1-32(29,30)24-23(28)12-8-3-2-7-11-19-20(22(27)15-21(19)26)14-13-17(25)16-31-18-9-5-4-6-10-18/h2,4-7,9-10,13-14,17,19-20,22,25,27H,3,8,11-12,15-16H2,1H3,(H,24,28)/b7-2-,14-13+/t17-,19-,20-,22-/m1/s1
• InChIKey: UQZVCDCIMBLVNR-TWYODKAFSA-N

Beschreibung

Anwendung

Human chondrocytes³ and mouse adrenal chromaffin cells⁴ were treated with sulprostone to study the biological effects of PGE₂.

Biochem./physiol. Wirkung

Selektiver EP₃-Prostanoid-Rezeptor-Agonist.

Sulprostone is an analog of prostaglandin E₂ (PGE₂)¹ and antagonizes vasopressin-induced antidiuretic responses in cells from rat renal inner medullae by a mechanism that involves activation of Rho.²

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Danger
• H-Sätze: H315,H319,H335,H360
• P-Sätze: P201 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Gefahreneinstufungen: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type ABEK (EN14387) respirator filter