S4441

D,L-Sulforaphane

≥90% (HPLC), liquid, phase II detoxification enzymes inducer

• Synonym(e): 1-Isothiocyanato-4-(methylsulfinyl)-butane
• Empirische Formel (Hill-System): C₆H₁₁NOS₂
• CAS-Nummer: 4478-93-7
• Molekulargewicht: 177.29
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724610
• NACRES: NA.77
• MDL number: MFCD00198068
• Assay: ≥90% (HPLC)
• Form: liquid
• Quality level: 200

Eigenschaften

• Produktname: DL-Sulforaphane, ≥90% (HPLC), synthetic, liquid
• SMILES string: CS(=O)CCCCN=C=S
• InChI: 1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3
• InChI key: SUVMJBTUFCVSAD-UHFFFAOYSA-N
• biological source: synthetic
• assay: ≥90% (HPLC)
• form: liquid
• solubility: DMSO: soluble 40 mg/mL, H₂O: insoluble
• compatibility: for use with ABI 7500
• shipped in: dry ice
• storage temp.: −20°C
• Quality Level: 200

Beschreibung

Application

LNCaP prostate cancer cells were treated with DL-Sulforaphane to study the effect on androgen receptor.[1] Effects on malathion toxicity was studied in rats by treating them with DL-Sulforaphane.[2]

Biochem/physiol Actions

Selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.

Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables.[3][4] It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.[3][5]

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)