Alle Fotos(1)
Wichtige Dokumente
S3884
Sauvagine
≥97% (HPLC)
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Alle Fotos(1)
About This Item
Empirische Formel (Hill-System):
C202H346N56O63S
CAS-Nummer:
Molekulargewicht:
4599.31
MDL-Nummer:
UNSPSC-Code:
12352200
NACRES:
NA.32
Assay
≥97% (HPLC)
Lagertemp.
−20°C
InChIKey
ILCVKEBXPLEGOY-ZLFMSJRASA-N
Amino Acid Sequence
Glp-Gly-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Ser-Leu-Glu-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2
Allgemeine Beschreibung
Sauvagine is a polypeptide derived from the frog skin. It belongs to the CRH (corticotropin releasing factor) family. Sauvagine is made of 40 amino acids. It may also be found in the brain of mammals.
Biochem./physiol. Wirkung
A peptide related to CRF and urotensin 1 that was first isolated from the skin of the frog Phyllomedusa sauvagei. Potent releaser of ACTH and β-endorphin from the anterior pituitary.
Sauvagine helps to liberate ACTH (adrenocorticotropic hormone) from the pituitary cells of rat. It has several important functions in the cardiovascular, endocrine and renal systems.
Sonstige Hinweise
Lyophilized from 0.1% TFA in H2O
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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Satoko Ise et al.
Brain research, 1234, 59-65 (2008-08-16)
An infant animal isolated from its mother emits vocalizations spanning from the audible to the ultrasonic. These vocalizations are believed to represent distress signals from the pup. However, the neurobiological basis for vocalizations elicited by isolation has not been well
Donald R Gehlert et al.
The Journal of pharmacology and experimental therapeutics, 341(3), 672-680 (2012-03-10)
Corticotropin-releasing factor (CRF) is the major hypothalamic neuropeptide responsible for stimulation of the hypothalamic-pituitary-adrenal axis (HPAA), resulting in the synthesis and release of glucocorticoids from the adrenal cortex. In a recent study, we reported the discovery of the CRF1 receptor
David A Lovejoy et al.
General and comparative endocrinology, 146(1), 1-8 (2006-02-14)
The corticotropin-releasing factor (CRF) family of peptides consists of four distinct paralogs found on separate chromosomes in vertebrates. Among invertebrates, the family has been relatively well characterized in the insects where at least 2 or 3 paralogs, a CRF-binding protein
James L Goodson et al.
Hormones and behavior, 50(2), 223-236 (2006-04-29)
Neuroendocrine factors that produce species differences in aggregation behavior ("sociality") are largely unknown, although relevant studies should yield important insights into mechanisms of affiliation and social evolution. We here focused on five species in the avian family Estrildidae that differ
Brian E Bernier et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(14), 5205-5212 (2011-04-08)
Alcohol addiction (alcoholism) is one of the most prevalent substance abuse disorders worldwide. Addiction is thought to arise, in part, from a maladaptive learning process in which enduring memories of drug experiences are formed. However, alcohol (ethanol) generally interferes with
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