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S3136

Sigma-Aldrich

[pGlu6]-Substance P Fragment 6-11

≥95% (HPLC)

Synonym(e):

pGlu-Phe-Phe-Gly-Leu-Met-NH2

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About This Item

Empirische Formel (Hill-System):
C36H49N7O7S
CAS-Nummer:
61123-13-5
Molekulargewicht:
723.88
MDL-Nummer:
MFCD00080132
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24899545

Assay

≥95% (HPLC)

UniProt-Hinterlegungsnummer

P20366

Lagertemp.

−20°C

SMILES String

CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(Cc2ccccc2)NC(=O)C3CCC(=O)N3)C(N)=O

Angaben zum Gen

human ... TAC1(6863)

Biochem./physiol. Wirkung

Substance P agonist; increased blood pressure when injected into cerebral ventricles of rat.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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M E Hall et al.
Peptides, 5(1), 85-89 (1984-01-01)
Substance P (SP) significantly reduced fighting in mice made aggressive by prolonged isolation. The N-terminal heptapeptide fragment SP (1-7) also reduced fighting. The C-terminal fragment SP(4-11) was without activity, while the shorter C-terminal fragment analog less than E-SP(7-11) significantly increased
W A Turski et al.
The International journal of biochemistry, 19(12), 1233-1236 (1987-01-01)
1. Peptidase(s) activity of nuclear and synaptosomal fraction from cortex and hippocampus of rat brain against pyroGlu6[125I-Tyr8]SP6-11 was evaluated in different concentration of Ca2+, Mg2+, K+ and Na+ in about "isotonic" conditions. 2. The effects of studied ions on the
U Wormser et al.
Neuropeptides, 16(1), 41-49 (1990-05-01)
Five synthetic N-methylated analogs (II-V) of the C-terminal hexapeptide analog of substance P (SP), [pGlu6]SP6-11 (I) were evaluated for their metabolic stability and in vitro spasmogenic activity. The metabolic resistance of the analogs was tested by two SP degrading systems
U Wormser et al.
Biochimica et biophysica acta, 798(1), 28-36 (1984-03-22)
Inactivation of substance P and its C-terminal hexapeptide analog [p-Glu6]substance P6-11 was studied in rat parotid and hypothalamic slices. It was found that in the parotid slice system the decay of substance P induced K+ release occurs concurrently with a
Y Iwabuchi et al.
Japanese journal of pharmacology, 58(3), 325-328 (1992-03-01)
The sialogogic response of submandibular glands to analogs of the C-terminal hexapeptide of substance P with various amino acids at the N-terminus was investigated in urethane-anesthetized rats. The rank order of potencies was as follows: SP greater than (pGlu6)SP6-11 much
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