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S0274

Sigma-Aldrich

[D-Arg1, D-Trp7,9, Leu11]-Substance P acetate salt

≥97% (HPLC)

Synonym(e):

Spantide I

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About This Item

Empirische Formel (Hill-System):
C75H108N20O13 · xC2H4O2
CAS-Nummer:
91224-37-2
Molekulargewicht:
1497.79 (free base basis)
UNSPSC-Code:
12352200

Assay

≥97% (HPLC)

Lagertemp.

−20°C

SMILES String

CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]6CCCN6C(=O)[C@H](CCCCN)NC(=O)[C@@H]7CCCN7C(=O)[C@H](N)CCCNC(N)=N)C(N)=O

Angaben zum Gen

human ... TACR1(6869)
mouse ... TACR1(21336)
rat ... TACR1(24807)

Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Trp-Phe-Trp-Leu-Leu-NH2

Biochem./physiol. Wirkung

Potent NK-1 tachykinin receptor antagonist.

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Radomir Radomirov et al.
Archives italiennes de biologie, 148(4), 377-388 (2011-02-11)
The evacuative motor responses of the anal canal and recto-anal reflexes during defecation were studied in an isolated rat recto-anal model preparation using (i) partitioned organ bath, (ii) electrical stimulation, (iii) balloon distension and (iv) morphological techniques. Electrical field stimulation
Hiroshi Onimaru et al.
The Journal of physiology, 590(7), 1615-1624 (2012-02-09)
The parafacial respiratory group (pFRG) in the rostral ventrolateral medulla of the newborn rat is predominantly composed of pre-inspiratory (Pre-I) neurons and is involved in respiratory rhythm generation. The subgroup located close to the ventral surface (at least partially overlapping
Qing Lin et al.
Molecular pain, 3, 30-30 (2007-10-27)
Acute cutaneous neurogenic inflammation initiated by activation of transient receptor potential vanilloid-1 (TRPV1) receptors following intradermal injection of capsaicin is mediated mainly by dorsal root reflexes (DRRs). Inflammatory neuropeptides are suggested to be released from primary afferent nociceptors participating in
P A Cragg et al.
Respiration physiology, 95(3), 295-310 (1994-03-01)
In the present study, we tested the hypothesis that substance P (SP) is an excitatory peptide to the rat carotid body and plays an important role in chemosensory excitation by hypoxia. Chemosensory discharge was recorded from the cut carotid sinus
A C Broiz et al.
Neuroscience, 201, 134-145 (2011-11-30)
The dorsal periaqueductal gray (dPAG) is the main output structure for the defensive response to proximal aversive stimulation. Panic-like responses, such as freezing and escape behaviors, often result when this structure is electrically stimulated. Freezing also ensues after termination of
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