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R7753

Rhapontin

Name: Rhapontin
Brand: SIGMA

≥99% (HPLC), from rhubarb

Synonym(e):

3,3′,5-Trihydroxy-4′-methoxystilben-3-O-β-D-glucosid, NSC 43321, Rhaponticin

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About This Item

Empirische Formel (Hill-System):

C₂₁H₂₄O₉

CAS-Nummer:

155-58-8

Molekulargewicht:

420.41

EG-Nummer:

205-845-0

MDL-Nummer:

MFCD00010117

UNSPSC-Code:

12352201

PubChem Substanz-ID:

24899400

Biologische Quelle

rhubarb

Assay

≥99% (HPLC)

Lagertemp.

2-8°C

SMILES String

COc1ccc(\C=C\c2cc(O)cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c2)cc1O

InChI

1S/C21H24O9/c1-28-16-5-4-11(8-15(16)24)2-3-12-6-13(23)9-14(7-12)29-21-20(27)19(26)18(25)17(10-22)30-21/h2-9,17-27H,10H2,1H3/b3-2+/t17-,18-,19+,20-,21-/m1/s1

InChIKey

GKAJCVFOJGXVIA-DXKBKAGUSA-N

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Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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Analysenzertifikate (COA)

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Rhaponticin from rhubarb rhizomes alleviates liver steatosis and improves blood glucose and lipid profiles in KK/Ay diabetic mice.

Jinlong Chen et al.

Planta medica, 75(5), 472-477 (2009-02-25)

We isolated several stilbene compounds including rhaponticin (3',5-dihydroxy-4'-methoxystilbene 3- O-beta- D-glucopyranoside) from extracts of rhubarb rhizomes. These compounds showed significant hypoglycemic effects in streptozotocin (STZ)-induced type 1 diabetic rats and mice. In this study, we investigated the effect of rhaponticin

Solvent effects on the absorption and fluorescence spectra of rhaponticin: experimental and theoretical studies.

Yang Sun et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 102, 194-199 (2012-12-12)

Rhaponticin (RH) possesses a variety of pharmacological activities including potent antitumor, antitumor-promoting, antithrombotic, antioxidant and vasorelaxant effects. The fundamental photophysics of RH is not well understood. In this work, solvent effect on the photoluminescence behavior of RH was studied by

One-step preparative separation of two polyhydroxystilbenes from Rheum likiangense Sam. by high-speed counter-current chromatography.

Xiaoyan Wang et al.

Phytochemical analysis : PCA, 23(6), 684-688 (2012-05-16)

The official rhubarb species have frequently been investigated for their hydroxyanthraquinone components and associated pharmacological properties. However, other unofficial rhubarb species were rarely studied until polyhydroxystilbenes (PHS), which commonly occur in the unofficial rhubarb, revealed a range of potential bioactivities.

Studies on the binding of rhaponticin with human serum albumin by molecular spectroscopy, modeling and equilibrium dialysis.

Yang Sun et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 87, 171-178 (2011-12-16)

Rhaponticin (RHA) possesses a variety of pharmacological activities including potent antitumor, antitumor-promoting, antithrombotic, antioxidant and vasorelaxant effects. In the solvation effect, RHA exhibited bathochromic shift in emission spectra with the increasing solvent polarity. The binding between RHA and HSA was

Pharmacokinetics, bioavailability and metabolism of rhaponticin in rat plasma by UHPLC-Q-TOF/MS and UHPLC-DAD-MSn.

Ying-Yong Zhao et al.

Bioanalysis, 4(6), 713-723 (2012-03-29)

Rhaponticin (Rheum L.) demonstrates a variety of pharmacological activities, including antitumor, antithrombotic and antioxidant effect. However, there is no information describing the pharmacokinetics, bioavailability and metabolism of rhaponticin after intravenous administration. UHPLC-Q-TOF/MS and UHPLC-multistage tandem MS methods were developed for

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